The Heart is a Lonely Hunter begins with a focus on the relationship between two close friends, John Singer and SpirosAntonapoulos, deaf-mutes who have lived together for several years. Antonapoulos becomes mentally ill, misbehaves, and despite attempts at intervention from Singer, is eventually put into an insane asylum away from town. Now alone, Singer moves into a new room. In the absence of his friend, how will Singer cope in a new surrounding?

Excerpt:

"In the town there were two mutes, and they were always together. Early every morning they would come out from the house where they lived and walk arm in arm down the street to work. The two friends were very different. The one who always steered the way was an obese and dreamy Greek. In the summer he would come out wearing a yellow or green polo shirt stuffed sloppily into his trousers in front and hanging loose behind."